A novel series of quinazoline is described; quinazolines (IVa-e) were prepared from the lead molecule anthranilic acid. On bromination of anthranilic acid 5-Bromo anthranillic acid was formed. It was treated with benzoyl chloride in the presence of dry pyridine to get 6-Bromo-2-ethyl-3, 1-benzoxazin-4-one, which was further treated with substituted aromatic amines to get 6-Bromo-phenyl-3-substituted quinazolines 4(3H) one, by substituting the aromatic ring at 3rd position. The structures of the synthesized compounds were assigned on the basis of UV analysis, IR, mass and PMR spectral data. All the products were screened against different strains of bacteria and fungi. Most of these compounds showed better inhibitory activity in comparison to the standard drugs.
Loading....